Emerging Roles of DDB2 in Cancer

International Journal of Molecular Sciences

Guillaume Drouot¹  Philippe Becuwe¹  Pauline Gilson²  Andréa Witz²  Alexandre Harlé²  Jean-Louis Merlin² 

[1] Faculté des Sciences et Technologies, Université de Lorraine, CNRS UMR 7039 CRAN, 54506 Vandœuvre-lès-Nancy CEDEX, France;Institut de Cancérologie de Lorraine, Service de Biopathologie, Université de Lorraine, CNRS UMR 7039 CRAN, 54519 Vandœuvre-lès-Nancy CEDEX, France;

关键词: ddb2;    dna repair;    cancers;    proliferation;    migration;    invasion;   

DOI  :  10.3390/ijms20205168

来源: DOAJ

【 摘 要 】

Damage-specific DNA-binding protein 2 (DDB2) was originally identified as a DNA damage recognition factor that facilitates global genomic nucleotide excision repair (GG-NER) in human cells. DDB2 also contributes to other essential biological processes such as chromatin remodeling, gene transcription, cell cycle regulation, and protein decay. Recently, the potential of DDB2 in the development and progression of various cancers has been described. DDB2 activity occurs at several stages of carcinogenesis including cancer cell proliferation, survival, epithelial to mesenchymal transition, migration and invasion, angiogenesis, and cancer stem cell formation. In this review, we focus on the current state of scientific knowledge regarding DDB2 biological effects in tumor development and the underlying molecular mechanisms. We also provide insights into the clinical consequences of DDB2 activity in cancers.

【 授权许可】

Unknown