A Potential “Vitaminic Strategy” against Caries and Halitosis

Applied Sciences

Daria Nicolosi¹  Laura Pietrangelo²  Angelica Perna²  Irene Magnifico²  Giulio Petronio Petronio²  Roberto Di Marco²  Marco Alfio Cutuli²  Noemi Venditti²  Germano Guerra² 

[1] Department of Drug and Health Sciences, Section of Microbiology, University of Catania, 95125 Catania, Italy;Department of Medicine and Health Sciences “V. Tiberio”, Università degli Studi del Molise, 86100 Campobasso, Italy;

关键词: Streptococcus mutans;    Fusobacterium nucleatum;    halitosis;    caries;    vitamin E;    α-tocopherol acetate;   

DOI  :  10.3390/app12052457

来源: DOAJ

【 摘 要 】

Streptococcus mutans and Fusobacterium nucleatum are two key bacteria of the oral microbiota. Due to their ability to form biofilms on oral tissues, they are both involved in the onset of the most common oral diseases. F. nucleatum is also the principal producer of hydrogen sulfide (H₂S), causative of the awkward bad breath of halitosis. In this study, the oral product Vea^® Oris, made by vitamin E and capric/caprylic acid only, was evaluated as a potential treatment for the most common oral diseases. Different concentrations of the product were tested against both S. mutans and F. nucleatum. The effect on planktonic and biofilm growth was investigated for both strains, and for F. nucleatum, the influence on H₂S production was evaluated. From our data, the product did not relevantly reduce the planktonic growth of both strains, whereas it validly counteracted biofilm assemblage. Moreover, an interesting trend of H₂S reduction was highlighted. Overall, these results suggested, on the one hand, a synergistic antimicrobial–antibiofilm action of two Vea^® Oris components and, together, potential modulation activity on H₂S production. However, the study should be implemented to confirm these only preliminary findings, certainly extending the panel of tested bacteria and using alternative methods of detection.

【 授权许可】

Unknown