Subgingival Periopathogens Assessment and Clinical Periodontal Evaluation of Gastric Cancer Patients—A Cross Sectional Pilot Study

Pathogens

Valeriu Marin Șurlin¹  Sandu Ramboiu¹  Ștefan Pătrașcu¹  Andreea Cristiana Didilescu²  Dan Ionuț Gheonea³  Bogdan Silviu Ungureanu³  Mihai Cucu⁴  Mirela Ghilusi⁵  Flavia Mirela Nicolae⁶  Petra Șurlin⁶  Igor Jelihovschi⁷  Luminita Smaranda Iancu⁷ 

[1] Department 1st of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania;Department of Embryology, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, 050474 Bucharest, Romania;Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania;Department of Genetics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania;Department of Pathology, Clinical County Emergency Hospital of Craiova, 200349 Craiova, Romania;Department of Periodontology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania;Department of Preventive Medicine and Interdisciplinarity, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iași, Romania;

关键词: Fusobacterium nucleatum;    periodontal disease;    gastric cancer;    periopathogens;   

DOI  :  10.3390/pathogens11030360

来源: DOAJ

【 摘 要 】

Oral microbiota have shown a higher bacterial diversity in patients with cancers of the digestive tract, with higher levels of periopathogens. Recent studies have shown that Fusobacterium links to gastro-intestinal neoplastic tissue and accelerates its progression, as well as worsening patient outcome. The present pilot study was carried out between February and December 2020 to evaluate the possible association between the abundance of some periopathogens (Fusobacterium nucleatum, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola and Tannerella forsythia) in subgingival plaque and periodontal status with characteristics of gastric cancer. The study was performed on a sample of 24 patients with gastric cancer from the 1st Department of Surgery and Department of Gastroenterology within the Clinical County Hospital of Emergency of Craiova, Romania. The patients’ oral cavity was examined, gingival crevicular samples were collected, and signs of periodontal disease were recorded. On the histopathological exam, the differentiation grade and size of the tumour were registered. Our results showed that, from the periopathogens studied, the most abundant bacteria were F. nucleatum followed by T. forsythia in all groups. In our present study, the strong correlation between tumour dimension and all periodontal parameters but also between tumour dimension and F. nucleatum could suggest a positive association between periodontal disease, tumoral growth and periopathogens implication in this process.

【 授权许可】

Unknown