Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway

Journal of King Saud University: Science

Mohamed Mohamed Soliman¹  Adil Aldhahrani¹  Mustafa Shukry²  Mohamed E. Abd El-Hack³  Asmaa R. Abou El-khair⁴  Samaa bakr⁴  Nora Ghanem⁴  Mayada R. Farag⁵ 

[1] Clinical Laboratory Sciences Department, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, KafrEl-Sheikh Governorate 33516, Egypt;Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt;Department of Zoology, Faculty of Science, Kafrelsheikh University, KafrEl-Sheikh Governorate 33516, Egypt;Forensic Medicine and Toxicology Department, Veterinary Medicine Faculty, Zagazig University, Zagazig 44519, Egypt;

关键词: Taurine;    Ipomoea carnea;    Oxidative injury;    Apoptosis;    Nuclear factor (erythroid-derived 2)-like 2;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objectives: The adverse deleterious influences of Ipomoea carnea on brain tissue and Taurine's relative ability to prevent this neurotoxicity have been examined. Methods: We utilized sixty Wistar male rats weighing 1752 g. The rats were allotted into 4 groups of fifteen each: The control group got saline i.p. daily for eight weeks; the Ipomoea carnea extract (ICE) group received ICE (15 mg/kg b.w./day) orally for eight weeks. Taurine-treated rats, in which rats were administered Taurine (200 mg·kg−1, i.p./Day) for 2 months. Taurine + ICE group in which rats were supplemented with (200 mg·kg−1, i.p. Taurine + ICE 15 mg/kg b.w./day orally) for 2 months. Result: The findings indicated that Ipomoea persuaded an increase in lipid peroxidation markers as well as a disruption in antioxidant homeostasis, along with brain and serum cholinesterase (AChE) elevated levels, tumor necrosis factor (TNF), total creatine phosphokinase (CPK), creatine phosphokinase isoenzymes BB (CPK-BB), and lactate dehydrogenase (LDH). A considerable drop (P < 0.05) in the brain superoxide dismutase (SOD), catalase (CAT), and GSH in Ipomoea carnea. SOD, CAT, and GSH levels were enhanced in the Taurine co-treated group but did not achieve control levels. Ipomoea Furthermore, Induced apoptosis in brain tissue by Ipomoea carnea reflected in pro-apoptotic Bax, P53, and caspase 3 overexpression., while taurine upregulated the anti-apoptotic Bcl2 in addition to Histopathologic, electron microscope, and immunohistological brain examination finding support our finding concerning the protective role of taurine. Conclusion: Our study proved the protective role of taurine as a supplement could recover Ipomoea carnea -induced oxidative changes and brain damage.

【 授权许可】

Unknown