Increased Lipid Peroxidation in Cerebrospinal Fluid and Plasma from Patients with Creutzfeldt–Jakob Disease

Neurobiology of Disease

Anatol Kontush¹  Christian Jacobi¹  Ulrike Beisiegel¹  Inga Zerr²  Andreas Schröter²  Sigrid Poser³  Carsten Buhmann³  Sönke Arlt³ 

[1] Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany;Neurological Clinic, University of Göttingen, Göttingen, Germany;Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany;

关键词: antioxidants;    cerebrospinal fluid;    Creutzfeldt–Jakob disease;    lipid peroxidation;    plasma;    prion disease;   

DOI  :  

来源: DOAJ

【 摘 要 】

Oxidative pathomechanisms play an important role in neurodegenerative diseases like Alzheimer's disease (AD). It has been shown that lipid peroxidation in cerebrospinal fluid (CSF) and plasma is increased in AD. To assess the role of oxidative stress in Creutzfeldt–Jakob disease (CJD), we investigated the oxidizability of lipids, the lipid composition and the levels of the antioxidants ascorbate and α-tocopherol in CSF and plasma of 15 CJD patients and 12 neurologically healthy controls. CSF and plasma lipid peroxidation was increased in CJD patients and polyunsaturated fatty acids were reduced in CSF of these patients. Ascorbate levels were lower in CSF and plasma of CJD patients, while α-tocopherol was found to be decreased in CSF but not in plasma. These results support the hypothesis that oxidative mechanisms are involved in the pathogenesis of CJD and provide a rationale for the use of antioxidants in the therapy of this disease.

【 授权许可】

Unknown