An Open Question: Is Non-Ionizing Radiation a Tool for Controlling Apoptosis-Induced Proliferation?

International Journal of Molecular Sciences

Wendy S. Beane¹  Luke J. Kinsey¹  Samantha J. Hack¹ 

[1] Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008, USA;

关键词: apoptosis;    non-ionizing radiation;    proliferation;    reactive oxygen species (ROS);    weak magnetic fields;    quantum biology;   

DOI  :  10.3390/ijms222011159

来源: DOAJ

【 摘 要 】

Non-ionizing radiation is commonly used in the clinical setting, despite its known ability to trigger oxidative stress and apoptosis, which can lead to damage and cell death. Although induction of cell death is typically considered harmful, apoptosis can also be beneficial in the right context. For example, cell death can serve as the signal for new tissue growth, such as in apoptosis-induced proliferation. Recent data has shown that exposure to non-ionizing radiation (such as weak static magnetic fields, weak radiofrequency magnetic fields, and weak electromagnetic fields) is able to modulate proliferation, both in cell culture and in living organisms (for example during tissue regeneration). This occurs via in vivo changes in the levels of reactive oxygen species (ROS), which are canonical activators of apoptosis. This review will describe the literature that highlights the tantalizing possibility that non-ionizing radiation could be used to manipulate apoptosis-induced proliferation to either promote growth (for regenerative medicine) or inhibit it (for cancer therapies). However, as uncontrolled growth can lead to tumorigenesis, much more research into this exciting and developing area is needed in order to realize its promise.

【 授权许可】

Unknown