Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants

NeuroImage: Clinical

Hillary Schwarb¹  Aaron T. Anderson²  Tracey Mencio Wszalek²  Daniel R. Smith³  Keith D. Paulsen⁴  Ryan T. Pohlig⁵  Matthew D.J. McGarry⁶  Graham R. Huesmann⁷  Curtis L. Johnson⁸  Bradley P. Sutton⁹ 

[1] Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States;Corresponding authors at: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States (G.R. Huesmann and H. Schwarb) and Department of Biomedical Engineering, University of Delaware, Newark, DE, United States (C.L. Johnson).;Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States;Interdisciplinary Health Sciences Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States;Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, United States;Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States;Carle Neuroscience Institute, Carle Foundation Hospital, Urbana, IL, United States;College of Health Sciences, University of Delaware, Newark, DE, United States;Department of Biomedical Engineering, University of Delaware, Newark, DE, United States;

关键词: Temporal lobe epilepsy;    Magnetic resonance elastography;    Hippocampus;    Stiffness;    Volume;   

DOI  :  

来源: DOAJ

【 摘 要 】

Mesial temporal lobe epilepsy (MTLE) is the most common form of refractory epilepsy. Common imaging biomarkers are often not sensitive enough to identify MTLE sufficiently early to facilitate the greatest benefit from surgical or pharmacological intervention. The objective of this work is to establish hippocampal stiffness measured with magnetic resonance elastography (MRE) as a biomarker for MTLE; we hypothesized that the epileptogenic hippocampus in MTLE is stiffer than the non-epileptogenic hippocampus. MRE was used to measure hippocampal stiffness in a group of patients with unilateral MTLE (n = 12) and a group of healthy comparison participants (n = 13). We calculated the ratio of hippocampal stiffness ipsilateral to epileptogenesis to the contralateral side for both groups. We found a higher hippocampal stiffness ratio in patients with MTLE compared with healthy participants (1.14 v. 0.99; p = 0.004), and that stiffness ratio differentiated MTLE from control groups effectively (AUC = 0.85). Hippocampal stiffness ratio, when added to volume ratio, an established MTLE biomarker, significantly improved the ability to differentiate the two groups (p = 0.038). Stiffness measured with MRE is sensitive to hippocampal pathology in MTLE and the addition of MRE to neuroimaging assessments may improve detection and characterization of the disease.

【 授权许可】

Unknown