An NMR-Based Metabolomic Approach to Unravel the Preventive Effect of Water-Soluble Extract from Dendrobium officinale Kimura & Migo on Streptozotocin-Induced Diabetes in Mice

Molecules

卷:22

Wenzong Zhu¹  Linlin Pan²  Hongchang Gao²  Hong Zheng²  Pengtao Xu²  Yongsheng Hu²  Ruohan Wang²  Jianjun Zhu³ 

[1] Department of Neurology Rehabilitation, Wenzhou Chinese Medicine Hospital, Wenzhou 325000, China;

[2] Institute of Metabonomics & Medical NMR, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China;

[3] Wenzhou Academy of Agricultural Sciences, Wenzhou 325006, China;

关键词: amino acid;    diabetes;    energy metabolism;    glucose-lowering;    liver;   

DOI  :  10.3390/molecules22091543

来源: DOAJ

【 摘 要 】

Dendrobium officinale Kimura & Migo (D. officinale) is a precious herbal medicine. In this study, we investigated metabolic mechanism underlying the effect of D. officinale water extract (DOWE) on diabetes prevention in mice after streptozotocin (STZ) exposure using NMR-based metabolomics. Interestingly, we found a decrease in blood glucose and an increase in liver glycogen in mice pretreated with DOWE after STZ exposure. The DOWE pretreatment significantly increased citrate and glutamine in the serum as well as creatine, alanine, leucine, isoleucine, valine, glutamine, glutathione and taurine in the liver of STZ-treated mice. Furthermore, serum glucose was significantly negatively correlated with citrate, pyruvate, alanine, isoleucine, histidine and glutamine in the serum as well as alanine and taurine in the liver. These findings suggest that the effect of DOWE on diabetes prevention may be linked to increases in liver glycogen and taurine as well as the up-regulation of energy and amino acid metabolism.

【 授权许可】

Unknown