Detrimental role of prolonged sleep deprivation on adult neurogenesis

Frontiers in Cellular Neuroscience

卷:9

Oscar eArias-Carrión¹  Andrea eHerrera-Solís¹  Sergio eMachado²  Susana eRocha³  Nuno Barbosa F Rocha³  Ti-Fei eYuan⁴  Eric eMurillo-Rodriguez⁵  José M Salas-Pacheco⁶  Fabio eGarcia-Garcia⁷  Carina eFernandes⁸ 

[1] Hospital General Dr. Manuel Gea González;

[2] Institute of Psychiatry of Federal University of Rio de Janeiro;

[3] Polytechnic Institute of Porto;

[4] School of Psychology, Nanjing Normal University;

[5] Universidad Anáhuac Mayab;

[6] Universidad Juárez del Estado de Durango;

[7] Universidad Veracruzana;

[8] University of Porto;

关键词: Hippocampus;    Neurogenesis;    Sleep;    Rhythm;    Antidepressants;    Hypnotic drug;   

DOI  :  10.3389/fncel.2015.00140

来源: DOAJ

【 摘 要 】

Adult mammalian brains continuously generate new neurons, a phenomenon called neurogenesis. Both environmental stimuli and endogenous factors are important regulators of neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and neurogenesis in brain function, such as learning, memory and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on neurogenesis.

【 授权许可】

Unknown