Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice

Journal of Neuroinflammation

卷:19

Junfa Wu¹  Li Liu¹  Yun Li¹  Yunhui Fan¹  Qiqi Zhang¹  Yi Wu¹  Jingjun Zhang¹  Hongyu Xie¹  Lu Luo¹  Meixi Liu¹  Congyu Jiang¹  Xiao Xiao² 

[1] Department of Rehabilitation Medicine, Huashan Hospital, Fudan University;

[2] Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Behavioral and Cognitive Neuroscience Center, Institute of Science and Technology for Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University;

关键词: Ischemic stroke;    Magnetic stimulation;    Pyroptosis;    Microglia;    Neuroinflammation;   

DOI  :  10.1186/s12974-022-02501-2

来源: DOAJ

【 摘 要 】

Highlights rTMS significantly ameliorated cerebral ischemia/reperfusion injury-induced locomotor deficits and neuronal damage in the early phase probably through the anti-inflammatory mechanism. The peak of pyroptosis was later than that of apoptosis during the early phase of stroke, and pyroptosis was mainly located and more severe in the peri-infarcted area compared with apoptosis. rTMS inhibited neuronal pyroptosis in the peri-infarcted area rather than at the border of infarcted core. rTMS modulated microglial polarization in the peri-infarcted area via inhibiting TLR4/NFκB/NLRP3 signaling pathway. Depletion of microglia eliminated the motor functional improvements after rTMS treatment.

【 授权许可】

Unknown