International Journal of Molecular Sciences | 卷:15 |
Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model | |
Tae Ryong Lee1  Yung Hyup Joo1  Bum-Ho Bin1  Eun-Gyung Cho1  Song Seok Shin1  Ai-Young Lee2  | |
[1] AmorePacific Corporation R&D Center, Yongin, Gyeonggi-do 446-729, Korea; | |
[2] Department of Dermatology, Dongguk University Ilsan Hospital, 814 Siksa-dong, Ilsandong-gu, Goyang-si, Gyenoggi-do 410-773, Korea; | |
关键词: valiolamine derivative; melanin; melanogenesis; tyrosinase; | |
DOI : 10.3390/ijms150712188 | |
来源: DOAJ |
【 摘 要 】
Hyper-pigmentation causes skin darkness and medical disorders, such aspost-inflammatory melanoderma and melasma. Therefore, the development ofanti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose,a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposedan alternative screening strategy to identify valiolamine derivatives with high skin permeability that act as anti-melanogenic agents when applied topically. In this study, we synthesized several valiolamine derivatives with enhanced lipophilicity and examined their inhibitory effects in a human skin model. N-(2-hydroxycyclohexyl)valiolamine (HV) possesses a stronger inhibitory effect on melanin production than voglibose in a human skin model, suggesting that HV is a more potent anti-melanogenic agent for the skin.
【 授权许可】
Unknown