Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model

International Journal of Molecular Sciences

Bum-Ho Bin¹  Yung Hyup Joo¹  Ai-Young Lee²  Song Seok Shin¹  Eun-Gyung Cho¹ 

[1] AmorePacific Corporation R&D Center, Yongin, Gyeonggi-do 446-729, Korea; E-Mails:;Department of Dermatology, Dongguk University Ilsan Hospital, 814 Siksa-dong, Ilsandong-gu, Goyang-si, Gyenoggi-do 410-773, Korea; E-Mail:

关键词: valiolamine derivative;    melanin;    melanogenesis;    tyrosinase;   

DOI  :  10.3390/ijms150712188

来源: mdpi

【 摘 要 】

Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose, a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposed an alternative screening strategy to identify valiolamine derivatives with high skin permeability that act as anti-melanogenic agents when applied topically. In this study, we synthesized several valiolamine derivatives with enhanced lipophilicity and examined their inhibitory effects in a human skin model. N-(2-hydroxycyclohexyl)valiolamine (HV) possesses a stronger inhibitory effect on melanin production than voglibose in a human skin model, suggesting that HV is a more potent anti-melanogenic agent for the skin.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.