Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study

International Journal of Infectious Diseases

卷:109

Antoine Bouquegneau¹  Marie Thys²  Monique Henket²  Renaud Louis³  Philippe Léonard³  Gilles Darcis³  Sophie De Worm³  Paul Meunier³  Perrine Canivet⁴  Anne-Françoise Rousseau⁵  Nathalie Maes⁶  Florence Labye⁷  Raphael Schils⁷  Julien Guiot⁷  Michel Moutschen⁸  Doriane Calmes⁸  Colin Desir⁸ 

[1] Corresponding author. Address: Department of Infectious Diseases, University Hospital of Liège, Avenue de l'hôpital 1, 4000 Liège, Belgium. Tel.: [phone].;

[2] Department of Biostatistics and Medico-Economic Information, University Hospital of Liège, Liège, Belgium;

[3] Department of Infectious Diseases, University Hospital of Liège, Liège, Belgium;

[4] Department of Intensive Care, University Hospital of Liège, Liège, Belgium;

[5] Department of Internal Medicine, University Hospital of Liège, Liège, Belgium;

[6] Department of Nephrology-Dialysis-Transplantation, University Hospital of Liège, Liège, Belgium;

[7] Department of Pneumology, University Hospital of Liège, Liège, Belgium;

[8] Department of Radiology, University Hospital of Liège, Liège, Belgium;

关键词: long COVID;    post-COVID;    COVID-19;    sequelae;    post-acute COVID-19;   

DOI  :  

来源: DOAJ

【 摘 要 】

ABSTRACT:Objectives: Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential mid- and long-term health sequelae. This prospective study of patients hospitalized with coronavirus disease 2019 (COVID-19) in Liège University Hospital, Belgium aimed to determine the persistent consequences of COVID-19. Methods: Patients admitted to the University Hospital of Liège with moderate-to-severe confirmed COVID-19, discharged between 2 March and 1 October 2020, were recruited prospectively. Follow-up at 3 and 6 months after hospital discharge included demographic and clinical data, biological data, pulmonary function tests (PFTs) and high-resolution computed tomography (CT) scans of the chest. Results: In total, 199 individuals were included in the analysis. Most patients received oxygen supplementation (80.4%). Six months after discharge, 47% and 32% of patients still had exertional dyspnoea and fatigue. PFTs at 3-month follow-up revealed a reduced diffusion capacity of carbon monoxide (mean 71.6 ± 18.6%), and this increased significantly at 6-month follow-up (P<0.0001). Chest CT scans showed a high prevalence (68.9% of the cohort) of persistent abnormalities, mainly ground glass opacities. Duration of hospitalization, intensive care unit admission and mechanical ventilation were not associated with the persistence of symptoms 3 months after discharge. Conclusion: The prevalence of persistent symptoms following hospitalization with COVID-19 is high and stable for up to 6 months after discharge. However, biological, functional and iconographic abnormalities improved significantly over time.

【 授权许可】

Unknown