Persistence of inflammatory and vascular mediators 5 months after hospitalization with COVID-19 infection

Frontiers in Medicine

Medicine

Asma Alamoudi¹  Anastasia Fries²  James Melhorn³  Nayia Petousi⁴  Julian Charles Knight⁵  Andrew Kwok⁶  Alexander J. Mentzer⁶  Nick P Talbot⁷  Emily Fraser⁸  Betty Raman⁹  Mark Philip Cassar⁹ 

[1] Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom;Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom;Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom;Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom;Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom;Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom;Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom;Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom;Wellcome Centre for Human Genetics, NDM, University of Oxford, Oxford, United Kingdom;Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom;Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom;Wellcome Centre for Human Genetics, NDM, University of Oxford, Oxford, United Kingdom;Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom;Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom;Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom;Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom;Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom;

关键词: COVID-19;    inflammation;    cytokines;    vascular injury;    post-COVID;   

DOI  :  10.3389/fmed.2023.1056506

 received in 2022-11-08, accepted in 2023-01-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background and aimIn acute severe COVID-19, patients present with lung inflammation and vascular injury, accompanied by an exaggerated cytokine response. In this study, our aim was to describe the inflammatory and vascular mediator profiles in patients who were previously hospitalized with COVID-19 pneumonitis, months after their recovery, and compare them with those in patients recovering from severe sepsis and in healthy controls.MethodsA total of 27 different cytokine, chemokine, vascular endothelial injury and angiogenic mediators were measured in the plasma of forty-nine patients 5.0 ± 1.9 (mean ± SD) months after they were hospitalized with COVID-19 pneumonia, eleven patients 5.4 ± 2.9 months after hospitalization with acute severe sepsis, and 18 healthy controls.ResultsCompared with healthy controls, IL-6, TNFα, SAA, CRP, Tie-2, Flt1, and PIGF were significantly increased in the post-COVID group, and IL-7 and bFGF were significantly reduced. While IL-6, PIGF, and CRP were also significantly elevated in post-Sepsis patients compared to controls, the observed differences in TNFα, Tie-2, Flt-1, IL-7 and bFGF were unique to the post-COVID group. TNFα levels significantly correlated with the severity of acute COVID-19 illness (spearman’s r = 0.30, p < 0.05). Furthermore, in post-COVID patients, IL-6 and CRP were each strongly negatively correlated with gas transfer factor %predicted (spearman’s r = –0.51 and r = –0.57, respectively, p < 0.002) and positively correlated with computed tomography (CT) abnormality scores at recovery (r = 0.28 and r = 0.46, p < 0.05, respectively).ConclusionA unique inflammatory and vascular endothelial damage mediator signature is found in plasma months following acute COVID-19 infection. Further research is required to determine its pathophysiological and clinical significance.

【 授权许可】

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Copyright © 2023 Melhorn, Alamoudi, Mentzer, Fraser, Fries, Cassar, Kwok, Knight, Raman, Talbot and Petousi.