Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia

Heliyon

卷:5

Tsuyoshi Miyaoka¹  Jun Horiguchi²  Misako Kanayama³  Michiharu Nagahama³  Ryosuke Arauchi³  Rei Wake³  Maiko Hayashida³  Toshiko Tsumori³  Shoko Miura³  Ilhamuddin Abdul Azis³  Koji Ohtsuki³  Muneto Izuhara³  Tomoko Araki³  Sadayuki Hashioka³  Rostia Arianna Abdullah³  Keiko Tsuchie³  Muhammad Alim Jaya³  Arata Oh-Nishi⁴  Masatoshi Inagaki⁴ 

[1] Corresponding author.;

[2] Department of Nursing, Faculty of Health and Welfare, Prefectural University of Hiroshima, Japan;

[3] Department of Psychiatry, Faculty of Medicine, Shimane University, Japan;

[4] Division of Immune-Neuropsychiatry, Faculty of Medicine, Shimane University, Japan;

关键词: Biochemistry;    Anatomy;    Cell biology;    Developmental biology;    Immunology;    Molecular biology;   

DOI  :  

来源: DOAJ

【 摘 要 】

A reduction of GABAergic markers in postmortem tissue is consistently found in schizophrenia. Importantly, these alterations in GABAergic neurons are not global, which means they are more prevalent among distinct subclasses of interneurons, including those that express the calcium binding protein parvalbumin.A decreased expression of parvalbumin in the hippocampus is a consistent observation not only in postmortem human schizophrenia patients, but also in a diverse number of rodent models of the disease.Meanwhile, previously we reported that the congenital hyperbilirubinemia model rats (Gunn rats), which is a mutant of the Wistar strain, showed behavioral abnormalities, for instance, hyperlocomotor activity, deficits of prepulse inhibition, inappropriate social interaction, impaired recognition memory similar with several rodent models of schizophrenia. Several animal studies linked the importance of palvalbumin in relation to abnormal hippocampal activity and schizophrenia-like behavior.Here, we show that parvalbumin positive cell density was significantly lower in the CA1, CA3 and the total hippocampus of Gunn rats (congenital hyperbilirubinemia model rats) compared to Wistar control rats. The correlations between serum UCB levels and loss of PV expression in the hippocampus were also detected. The decreases in the PV-expression in the hippocampus might suggest an association of the behavioral abnormalities as schizophrenia-like behaviors of Gunn rats, compared to the Wistar control rats.

【 授权许可】

Unknown