期刊论文详细信息
Microorganisms 卷:10
Probabilistic Analysis of a French Legionellosis Outbreak Shows Potential Role of Wastewater Basin
France Wallet1  Pierre-André Cabanes1  Leila Fontenay2 
[1] EDF-Services des Etudes Médicales, 4 Rue Floréal, 75017 Paris, France;
[2] Société de Calcul Mathématique, 111 Faubourg Saint Honoré, 75008 Paris, France;
关键词: air-borne infections;    epidemiology;    Legionella;    legionellosis;    Legionnaires’ disease;    outbreaks;   
DOI  :  10.3390/microorganisms10020422
来源: DOAJ
【 摘 要 】

Based on the data from a French outbreak of legionellosis, a probabilistic approach was developed to analyze and assess the potential role of several suspected sources of contamination. Potential dates of exposure of all cases were determined using back-calculation, using two probability distribution functions to model incubation period. A probabilistic analysis and risk assessment were then used to determine the most probable sources of contamination for each wave of the outbreak. The risk assessment was based on parameters representing emission and dispersion of Legionella: level and duration of emission; aerosol dispersion capacity; and probability of potential exposure for each patient. Four types of facilities containing the Legionella epidemic strain were analyzed: cooling towers, aerated wastewater basins, high pressure water cleaners, and car wash stations. The results highlighted the potential role of an aerated wastewater basin in the outbreak in addition to cooling towers. The role of high-pressure water cleaners and car wash stations appeared to be non-significant. This study also reveals the lack of knowledge on facility parameters that can be useful for microbial risk assessments. This type of probabilistic analysis can be used to quantitatively assess the risk for various facilities in order to manage a legionellosis outbreak.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次