Expression Analysis of Protein Inhibitor of Activated STAT in Inflammatory Demyelinating Polyradiculoneuropathy

Frontiers in Immunology

卷:12

Naghme Nazer¹  Fwad Nicknafs²  Arezou Sayad²  Soudeh Ghafouri-Fard²  Bashdar Mahmud Hussen³  Mohammad Taheri⁴ 

[1] Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran;

[2] Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

[3] Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Iraq;

[4] Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: protein inhibitor of activated STAT;    PIAS;    inflammatory demyelinating polyradiculoneuropathy;    AIDP;    CIDP;   

DOI  :  10.3389/fimmu.2021.659038

来源: DOAJ

【 摘 要 】

Protein inhibitors of activated STAT (PIAS) are involved in the regulation of the JAK/STAT signaling pathway and have interactions with NF-κB, p73 and p53. These proteins regulate immune responses; therefore dysregulation in their expression leads to several immune-mediated disorders. In the present study, we examined expression of PIAS1-4 in peripheral blood of patients with acute/chronic inflammatory demyelinating polyradiculoneuropathy (AIDP/CIDP) compared with healthy subjects. We demonstrated down-regulation of all PIAS genes in both AIDP and CIDP cases compared with controls. Similarly, comparisons in gender-based groups revealed down-regulation of these gene0s in patients of each gender compared with gender-matched controls. There was no significant difference in expression of PIAS genes between AIDP and CIDP cases. Based on the area under the receiver operating characteristic curves, PIAS1-4 genes could distinguish between inflammatory demyelinating polyradiculoneuropathy and healthy status with accuracy values of 0.87, 0.87, 0.79 and 0.80, respectively. In differentiation between AIDP cases and healthy controls, these values were 0.92, 0.92, 0.83 and 0.86, respectively. Finally, PIAS1-4 genes could discriminate CIDP from healthy status with accuracy values of 0.82, 0.83, 0.75 and 0.75, respectively. The current study underscores the role of PIAS genes in the pathogenesis of inflammatory demyelinating polyradiculoneuropathy and their potential usage as biomarkers.

【 授权许可】

Unknown