Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing a 5-Trifluoromethylpyridyl Moiety

Molecules

卷:21

Haibing He¹  Hong Dai¹  Yuan Fang¹  Jia Chen¹  Yujun Shi¹  Hong Li²  Baojiang Dai³ 

[1] College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China;

[2] Nantong Fengtian Chemical Industry Co. Ltd., Nantong 226005, China;

[3] School of Chemical and Biological Engineering, Nantong Vocational University, Nantong 226007, China;

关键词: pyrazole oxime;    5-trifluoromethylpyridyl;    synthesis;    bioactivity;   

DOI  :  10.3390/molecules21030276

来源: DOAJ

【 摘 要 】

In this study, in order to find novel biologically active pyrazole oxime compounds, a series of pyrazole oxime derivatives containing a 5-trifluoromethylpyridyl moiety were synthesized. Preliminary bioassays indicated that most title compounds were found to display good to excellent acaricidal activity against Tetranychus cinnabarinus at a concentration of 200 μg/mL, and some designed compounds still showed excellent acaricidal activity against Tetranychus cinnabarinus at the concentration of 10 μg/mL, especially since the inhibition rates of compounds 8e, 8f, 8l, 8m, 8n, 8p, and 8q were all 100.00%. Interestingly, some target compounds exhibited moderate to good insecticidal activities against Plutella xylostella and Aphis craccivora at a concentration of 200 μg/mL; furthermore, compounds 8e and 8l possessed outstanding insecticidal activities against Plutella xylostella under the concentration of 50 μg/mL.

【 授权许可】

Unknown