Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds

Molecules

Alejandro F. Barrero¹  M. Mar Herrador¹  Pilar Arteaga¹  Jesús F. Arteaga¹ 

[1] ¹Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, Campus de Fuente Nueva, s/n. 18071 Granada, Spain

关键词: communic acids;    labdanes;    bioactivity;    synthesis;    chirons;   

DOI  :  10.3390/molecules17021448

来源: mdpi

【 摘 要 】

Communic acids are diterpenes with labdane skeletons found in many plant species, mainly conifers, predominating in the genus Juniperus (fam. Cupresaceae). In this review we briefly describe their distribution and different biological activities (anti- bacterial, antitumoral, hypolipidemic, relaxing smooth muscle, etc.). This paper also includes a detailed explanation of their use as chiral building blocks for the synthesis of bioactive natural products. Among other uses, communic acids have proven useful as chirons for the synthesis of quassinoids (formal), abietane antioxidants, ambrox and other perfume fixatives, podolactone herbicides, etc., featuring shorter and more efficient processes.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.