Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain

International Journal of Molecular Sciences

Zining Cui¹  Xinghai Li³  Fang Tian² 

[1] Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China;State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China; E-Mail:;Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China; E-Mail:

关键词: diacylhydrazide;    aliphatic chain;    synthesis;    bioactivity;   

DOI  :  10.3390/ijms15058941

来源: mdpi

【 摘 要 】

A series of 5-substituted-2-furoyl diacylhydazide derivatives with aliphatic chain were designed and synthesized. Their structures were characterized by IR, ¹H NMR, elemental analysis, and X-ray single crystal diffraction. The anti-tumor bioassay revealed that some title compounds exhibited promising activity against the selected cancer cell lines, especially against the human promyelocytic leukemic cells (HL-60). Their fungicidal tests indicated that most of the title compounds showed significant anti-fungal activity. The preliminary structure-activity relationship showed that the aliphatic chain length and differences in the R² group had obvious effects on the anti-tumor and anti-fungal activities. The bioassay results demonstrated that the title compounds hold great promise as novel lead compounds for further drug discovery.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland