A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases

Journal of Nanobiotechnology

卷:20

Siqin He¹  Kun Xiong¹  Huile Gao¹  Jiajia Gui¹  Yao Fu¹  Meiwan Chen² 

[1] Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University;

[2] State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau;

关键词: Drug delivery;    Lung;    Pulmonary infectious disease;    Targeting;    Therapeutic strategies;   

DOI  :  10.1186/s12951-022-01307-x

来源: DOAJ

【 摘 要 】

Abstract Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass effect and high bioavailability, which provides an important means to deliver therapeutics directly to lung lesions. Starting from the structural characteristics of the lungs and the biological barriers for achieving efficient delivery, we aim to review literatures in the past decade regarding the pulmonary delivery strategies used to treat infectious lung diseases. Hopefully, this review article offers new insights into the future development of therapeutic strategies against pulmonary infectious diseases from a delivery point of view. Graphical Abstract

【 授权许可】

Unknown