Novel pathomechanisms in inflammatory neuropathies

Journal of Neuroinflammation

卷:14

Bernd C. Kieseier¹  Heinz Wiendl²  Gerd Meyer zu Horste²  David Schafflick² 

[1] Department of Neurology, Medical Faculty, Heinrich-Heine-University;

[2] Department of Neurology, Westfälische Wilhems-University;

关键词: Experimental autoimmune neuritis;    Guillain-Barré syndrome;    Chronic inflammatory demyelinating polyneuropathy;    Animal model;    Th17 cells;   

DOI  :  10.1186/s12974-017-1001-8

来源: DOAJ

【 摘 要 】

Abstract Inflammatory neuropathies are rare autoimmune-mediated disorders affecting the peripheral nervous system. Considerable progress has recently been made in understanding pathomechanisms of these disorders which will be essential for developing novel diagnostic and therapeutic strategies in the future. Here, we summarize our current understanding of antigenic targets and the relevance of new immunological concepts for inflammatory neuropathies. In addition, we provide an overview of available animal models of acute and chronic variants and how new diagnostic tools such as magnetic resonance imaging and novel therapeutic candidates will benefit patients with inflammatory neuropathies in the future. This review thus illustrates the gap between pre-clinical and clinical findings and aims to outline future directions of development.

【 授权许可】

Unknown