Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammation

Journal of Neuroinflammation

Eroboghene E. Ubogu¹  Eric S. Helton¹  Chaoling Dong¹  Steven P. Palladino¹  Kelsey M. Greathouse¹ 

[1] Department of Neurology, Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, The University of Alabama at Birmingham, 1825 University Boulevard, Room 1131, Birmingham 35294-0017, AL, USA

关键词: Two-photon microscopy;    Spontaneous autoimmune peripheral polyneuropathy;    Neuropathic pain;    Leukocyte trafficking;    Intravital microscopy;    Guillain-Barré syndrome;    Experimental autoimmune neuritis;    Chronic inflammatory demyelinating polyradiculoneuropathy;    Blood-nerve barrier;   

Others  :  1235620
DOI  :  10.1186/s12974-015-0469-3

 received in 2015-05-25, accepted in 2015-12-24,  发布年份 2016

【 摘 要 】

Peripheral neuroinflammation is characterized by hematogenous mononuclear leukocyte infiltration into peripheral nerves. Despite significant clinical knowledge, advancements in molecular biology and progress in developing specific drugs for inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis, there are currently no specific therapies that modulate pathogenic peripheral nerve inflammation. Modeling leukocyte trafficking at the blood-nerve barrier using a reliable human in vitro model and potential intravital microscopy techniques in representative animal models guided by human observational data should facilitate the targeted modulation of the complex inflammatory cascade needed to develop safe and efficacious therapeutics for immune-mediated neuropathies and chronic neuropathic pain.

【 授权许可】

   
2016 Greathouse et al.

【 图 表 】

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