International Journal of Molecular Sciences | 卷:14 |
Toll-Like Receptors in Atherosclerosis | |
关键词: pattern recognition; inflammation; toll-like receptors; innate immunity; atherosclerosis; cardiovascular disease; macrophages; dendritic cells; | |
DOI : 10.3390/ijms140714008 | |
来源: DOAJ |
【 摘 要 】
Atherosclerosis, the leading cause of cardiovascular disease (CVD), is driven by inflammation. Increasing evidence suggests that toll-like receptors (TLRs) are key orchestrators of the atherosclerotic disease process. Interestingly, a distinct picture is being revealed for individual receptors in atherosclerosis. TLRs exhibit a complex nature enabling the detection of multiple motifs named danger-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). Activation of these receptors triggers an intracellular signalling cascade mediated through MyD88 or TRIF, leading to the production of pro- and anti-inflammatory cytokines. In this review we explore key novel findings pertaining to TLR signalling in atherosclerosis, including recently described endosomal TLRs and future directions in TLR research.
【 授权许可】
Unknown