Toll-Like Receptors in Atherosclerosis

International Journal of Molecular Sciences

Mika Falck-Hansen¹  Christina Kassiteridi¹ 

[1] Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK;

关键词: pattern recognition;    inflammation;    toll-like receptors;    innate immunity;    atherosclerosis;    cardiovascular disease;    macrophages;    dendritic cells;   

DOI  :  10.3390/ijms140714008

来源: mdpi

【 摘 要 】

Atherosclerosis, the leading cause of cardiovascular disease (CVD), is driven by inflammation. Increasing evidence suggests that toll-like receptors (TLRs) are key orchestrators of the atherosclerotic disease process. Interestingly, a distinct picture is being revealed for individual receptors in atherosclerosis. TLRs exhibit a complex nature enabling the detection of multiple motifs named danger-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). Activation of these receptors triggers an intracellular signalling cascade mediated through MyD88 or TRIF, leading to the production of pro- and anti-inflammatory cytokines. In this review we explore key novel findings pertaining to TLR signalling in atherosclerosis, including recently described endosomal TLRs and future directions in TLR research.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland