Toll-like receptors: their roles in pathomechanisms of atopic dermatitis

Frontiers in Immunology

Immunology

Risa Tamagawa-Mineoka¹ 

[1] Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan;

关键词: atopic dermatitis;    barrier;    inflammation;    innate immunity;    stratum corneum;    skin;    toll-like receptors;   

DOI  :  10.3389/fimmu.2023.1239244

 received in 2023-06-13, accepted in 2023-08-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

The skin functions as a physical barrier and represents the first line of the innate immune system. There is increasing evidence that toll-like receptors (TLRs) are involved in the pathomechanisms of not only infectious diseases, but also non-infectious inflammatory diseases. Interestingly, it has been demonstrated that TLRs recognize both exogenous threats, e.g. bacteria and viruses, and endogenous danger signals related to inflammation, cell necrosis, or tissue damage. Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease, which is associated with impaired skin barrier function, increased skin irritability to non-specific stimuli, and percutaneous sensitization. The impairment of skin barrier function in AD allows various stimuli, such as potential allergens and pathogens, to penetrate the skin and activate the innate immune system, including TLR signaling, which can lead to the development of adaptive immune reactions. In this review, I summarize the current understanding of the roles of TLR signaling in the pathogenesis of AD, with special emphasis on skin barrier function and inflammation.

【 授权许可】

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