Intervertebral Disk Degeneration: The Microenvironment and Tissue Engineering Strategies

Frontiers in Bioengineering and Biotechnology

卷:9

Xin Zhao¹  Xinlong Ma²  Qiang Yang²  Xun Sun²  Yiming Dou² 

[1] Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong;

[2] Department of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, China;

关键词: intervertebral disk degeneration;    microenvironment;    tissue engineering;    scaffold;    regeneration;    disk herniation;   

DOI  :  10.3389/fbioe.2021.592118

来源: DOAJ

【 摘 要 】

Intervertebral disk degeneration (IVDD) is a leading cause of disability. The degeneration is inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on the relief of symptoms, not the intrinsic regeneration of the intervertebral disk (IVD). Tissue engineering is a promising strategy for IVDD due to its ability to restore a healthy microenvironment and promote IVD regeneration. This review briefly summarizes the IVD anatomy and composition and then sets out elements of the microenvironment and the interactions. We rationalized different scaffolds based on tissue engineering strategies used recently. To fulfill the complete restoration of a healthy IVD microenvironment, we propose that various tissue engineering strategies should be combined and customized to create personalized therapeutic strategies for each individual.

【 授权许可】

Unknown