Phase Coupled Firing of Prefrontal Parvalbumin Interneuron With High Frequency Oscillations

Frontiers in Cellular Neuroscience

卷:14

Longnian Lin¹  Jiamin Xu³  Mengmeng Wu³  Lina Wang³  Yanting Yao³ 

[1] Brain and Spinal Cord Clinical Center, Tongji University, Shanghai, China;

[2] NYU–ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai, China;

[3] Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Life Sciences, East China Normal University, Shanghai, China;

关键词: optogenetics;    prefrontal cortex;    parvalbumin interneurons;    firing pattern;    high frequency oscillation;   

DOI  :  10.3389/fncel.2020.610741

来源: DOAJ

【 摘 要 】

The prefrontal cortex (PFC) plays a central role in executive functions and inhibitory control over many cognitive behaviors. Dynamic changes in local field potentials (LFPs), such as gamma oscillation, have been hypothesized to be important for attentive behaviors and modulated by local interneurons such as parvalbumin (PV) cells. However, the precise relationships between the firing patterns of PV interneurons and temporal dynamics of PFC activities remains elusive. In this study, by combining in vivo electrophysiological recordings with optogenetics, we investigated the activities of prefrontal PV interneurons and categorized them into three subtypes based on their distinct firing rates under different behavioral states. Interestingly, all the three subtypes of interneurons showed strong phase-locked firing to cortical high frequency oscillations (HFOs), but not to theta or gamma oscillations, despite of behavior states. Moreover, we showed that sustained optogenetic stimulation (over a period of 10 s) of PV interneurons can consequently modulate the activities of local pyramidal neurons. Interestingly, such optogenetic manipulations only showed moderate effects on LFPs in the PFC. We conclude that prefrontal PV interneurons are consist of several subclasses of cells with distinct state-dependent modulation of firing rates, selectively coupled to HFOs.

【 授权许可】

Unknown