Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms

Frontiers in Endocrinology

Endocrinology

Juan Ren¹  Sabine Richard¹  Frédéric Flamant¹ 

[1] Institut de Génomique Fonctionnelle de Lyon, UMR5242, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard-Lyon 1, USC1370 Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, Lyon, France;

关键词: brain development;    parvalbumin interneurons;    thyroid hormone receptors;    animal models;    hypothyroidism;    neurological disorders;   

DOI  :  10.3389/fendo.2023.1256877

 received in 2023-07-11, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data obtained in the past years in animal models have pinpointed GABAergic neurons as a major target of TH signaling during development, which opens up new perspectives to further investigate the mechanisms by which TH affects brain development. The aim of the present review is to gather the available information about the involvement of TH in the maturation of GABAergic neurons. After giving an overview of the kinds of neurological disorders that may arise from disruption of TH signaling during brain development in humans, we will take a historical perspective to show how rodent models of hypothyroidism have gradually pointed to GABAergic neurons as a main target of TH signaling during brain development. The third part of this review underscores the challenges that are encountered when conducting gene expression studies to investigate the molecular mechanisms that are at play downstream of TH receptors during brain development. Unravelling the mechanisms of action of TH in the developing brain should help make progress in the prevention and treatment of several neurological disorders, including autism and epilepsy.

【 授权许可】

Unknown   
Copyright © 2023 Richard, Ren and Flamant