Can telomere length predict bone health? A review of current evidence

Bosnian Journal of Basic Medical Sciences

Sok Kuan Wong¹  Soelaiman Ima-Nirwana¹  Kok-YongChin² 

[1] Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia ;

[2] Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia;

关键词: Bone health;    osteoblast;    osteoclast;    osteoporosis;    telomerase;    telomere;   

DOI  :  10.17305/bjbms.2020.4664

来源: DOAJ

【 摘 要 】

Telomeres are repetitive DNA sequences located at the end of chromosomes, which serve as a protective barrier against chromosomal deterioration during cell division. Approximately 50–200 base pairs of nucleotides are lost per cell division and new repetitive nucleotides are added by the enzyme telomerase allowing telomere maintenance. Telomere shortening has been proposed as an indicator for biological ageing, but its relationship with age-related osteoporosis is ambiguous. We summarize the current evidence on the relationship between telomere length and bone health in experimental and epidemiological studies, which may serve as a scientific reference for the development of novel diagnostic markers of osteoporosis or novel therapeutics targeting telomere and telomerase in bone cells to treat osteoporosis.

【 授权许可】

Unknown