Influence of Iron on Bone Homeostasis

Pharmaceuticals

György Paragh¹  Enikő Balogh²  Viktória Jeney² 

[1] Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary;Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary;

关键词: bone homeostasis;    iron overload;    iron deficiency;    osteoclast;    osteoblast;    osteoporosis;   

DOI  :  10.3390/ph11040107

来源: DOAJ

【 摘 要 】

Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be tightly regulated and orchestrated. Iron overload as well as iron deficiency disrupt the delicate balance between bone destruction and production, via influencing osteoclast and osteoblast differentiation as well as activity. Iron overload as well as iron deficiency are accompanied by weakened bones, suggesting that balanced bone homeostasis requires optimal—not too low, not too high—iron levels. The goal of this review is to summarize our current knowledge about how imbalanced iron influence skeletal health. Better understanding of this complex process may help the development of novel therapeutic approaches to deal with the pathologic effects of altered iron levels on bone.

【 授权许可】

Unknown