The Regulation of Bone Metabolism and Disorders by Wnt Signaling

International Journal of Molecular Sciences

Shunsuke Uehara¹  Masanori Okamoto²  Mitsuru Saito³  Keishi Marumo³  Kazuhiro Maeda³  Tomohiro Kayama³  Akihiro Ishihara⁴  Masanori Koide⁵  Yasuhiro Kobayashi⁵ 

[1] Department of Biochemistry, Matsumoto Dental University, 1780 Gohara Hiro-Oka, Shiojiri, Nagano 399-0781, Japan;Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan;Department of Orthopaedic Surgery, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan;Hiruma dental clinic, 5-34-16-4F Kameari, Katsushika-ku, Tokyo 125-0061, Japan;Institute for Oral Science, Matsumoto Dental University, 1780 Gohara Hiro-Oka, Shiojiri, Nagano 399-0781, Japan;

关键词: osteoclast;    osteoblast;    osteocyte;    wnt;    sclerostin;    osteoporosis;    romosozumab;    osteoarthritis;    rheumatoid arthritis;    skeletal-related events;   

DOI  :  10.3390/ijms20225525

来源: DOAJ

【 摘 要 】

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a cytokine involved in various biological phenomena including ontogeny, morphogenesis, carcinogenesis, and maintenance of stem cells. The Wnt signaling pathway can be classified into two main pathways: canonical and non-canonical. Of these, the canonical Wnt signaling pathway promotes osteogenesis. Sclerostin produced by osteocytes is an inhibitor of this pathway, thereby inhibiting osteogenesis. Recently, osteoporosis treatment using an anti-sclerostin therapy has been introduced. In this review, the basics of Wnt signaling, its role in bone metabolism and its involvement in skeletal disorders have been covered. Furthermore, the clinical significance and future scopes of Wnt signaling in osteoporosis, osteoarthritis, rheumatoid arthritis and neoplasia are discussed.

【 授权许可】

Unknown