Cellular and molecular effects of thiazolidinediones on bone cells: a review

International Journal of Biochemistry and Molecular Biology

Daniel Chappard¹  Guillaume Mabilleau¹  Michel F. Baslé¹ 

关键词: Thiazolidinediones;    osteoclast;    osteoblast;    osteocyte;    PPARγ;    diabetes mellitus;   

DOI  :  

学科分类：生物化学/生物物理

来源: e-Century Publishing Corporation

【 摘 要 】

Thiazolidinediones represent a class of molecules used in the treatment of type 2 diabetes mellitus. Despite interesting effects in lowering blood glucose and HbA1c levels durably, an augmentation of the fracture risk in women has emerged in the past years. This review is providing the readers with information about the cellular and molecular mechanisms involved in bone and bone cells in response to these drugs.

【 授权许可】

Unknown