Mitochondria’s Role in Skin Ageing

Biology

卷:8

Roisin Stout¹  Mark Birch-Machin¹ 

[1] Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK;

关键词: mitochondria;    skin;    ageing;    reactive oxygen species;    photoageing;   

DOI  :  10.3390/biology8020029

来源: DOAJ

【 摘 要 】

Skin ageing is the result of a loss of cellular function, which can be further accelerated by external factors. Mitochondria have important roles in skin function, and mitochondrial damage has been found to accumulate with age in skin cells, but also in response to solar light and pollution. There is increasing evidence that mitochondrial dysfunction and oxidative stress are key features in all ageing tissues, including skin. This is directly linked to skin ageing phenotypes: wrinkle formation, hair greying and loss, uneven pigmentation and decreased wound healing. The loss of barrier function during skin ageing increases susceptibility to infection and affects wound healing. Therefore, an understanding of the mechanisms involved is important clinically and also for the development of antiageing skin care products.

【 授权许可】

Unknown