The Significance of Mitochondrial Dysfunction in Cancer

International Journal of Molecular Sciences

卷:21

Weiqin Lu¹  Jianjia Ma¹  Yongde Luo² 

[1] Division of Gastroenterology and Hepatology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA;

[2] School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325000, China;

关键词: mitochondria;    dysfunction;    cancers;    TCA cycle;    electron transport chain;    oxidative phosphorylation;   

DOI  :  10.3390/ijms21165598

来源: DOAJ

【 摘 要 】

As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrial dysfunction, either due to the TCA cycle enzyme defects, mitochondrial DNA genetic mutations, defective mitochondrial electron transport chain, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been observed in a wide spectrum of human cancers. In this review, we summarize mitochondrial dysfunction induced by these alterations that promote human cancers.

【 授权许可】

Unknown