Emerging Role of TCA Cycle-Related Enzymes in Human Diseases

International Journal of Molecular Sciences

卷:22

Takako Saito¹  Miki Suzuki²  Woojin Kang²  Kenji Miyado² 

[1] Department of Applied Life Sciences, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan;

[2] Department of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan;

关键词: TCA cycle;    human diseases;    TCA cycle-related enzymes;    calcium oscillations;    mitochondria;   

DOI  :  10.3390/ijms222313057

来源: DOAJ

【 摘 要 】

The tricarboxylic acid (TCA) cycle is the main source of cellular energy and participates in many metabolic pathways in cells. Recent reports indicate that dysfunction of TCA cycle-related enzymes causes human diseases, such as neurometabolic disorders and tumors, have attracted increasing interest in their unexplained roles. The diseases which develop as a consequence of loss or dysfunction of TCA cycle-related enzymes are distinct, suggesting that each enzyme has a unique function. This review aims to provide a comprehensive overview of the relationship between each TCA cycle-related enzyme and human diseases. We also discuss their functions in the context of both mitochondrial and extra-mitochondrial (or cytoplasmic) enzymes.

【 授权许可】

Unknown