Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer’s-type dementia

Cell Reports Medicine

卷:2

Tomohiro Kawahara¹  Yu Taniguchi²  Shoji Shinkai³  Yodai Kobayashi⁴  Akihiko Kitamura⁵  Takuji Yamada⁵  Noriyuki Kohda⁵  Kazunari Ushida⁵  Hirotsugu Shiroma⁶  Takahiro Kariya⁶  Sayaka Tsuchida⁷  Atsushi Ueda⁷ 

[1] Center for Health and Environmental Risk Research, National Institute for Environmental Studies, Ibaraki, Japan;

[2] Kagawa Nutrition University, Saitama, Japan;

[3] Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd., Shiga, Japan;

[4] College of Bioscience and Biotechnology, Chubu University, Aichi, Japan;

[5] Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan;

[6] School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan;

关键词: microbiota-gut-brain axis;    gut microbiome-based intervention;    Faecalibacterium prausnitzii;    Alzheimer’s disease;    mild cognitive impairment;    MCI;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Evidence linking the gut-brain axis to Alzheimer’s disease (AD) is accumulating, but the characteristics of causally important microbes are poorly understood. We perform a fecal microbiome analysis in healthy subjects and those with mild cognitive impairment (MCI) and AD. We find that Faecalibacterium prausnitzii (F. prausnitzii) correlates with cognitive scores and decreases in the MCI group compared with the healthy group. Two isolated strains from the healthy group, live Fp360 and pasteurized Fp14, improve cognitive impairment in an AD mouse model. Whole-genome comparison of isolated strains reveals specific orthologs that are found only in the effective strains and are more abundant in the healthy group compared with the MCI group. Metabolome and RNA sequencing analyses of mouse brains provides mechanistic insights into the relationship between the efficacy of pasteurized Fp14, oxidative stress, and mitochondrial function. We conclude that F. prausnitzii strains with these specific orthologs are candidates for gut microbiome-based intervention in Alzheimer's-type dementia.

【 授权许可】

Unknown