Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Xia Liu¹  Nengneng Zheng²  Weiming Hu³  Jie Gao⁴  Zongxin Ling⁵  Yiwen Cheng⁵  Wenhui Lei⁶  Qingming Kong⁷  Li Shao⁸ 

[1] Department of Intensive Care Unit, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;Department of Obstetrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;Department of Psychiatry, Quzhou Third Hospital, Quzhou, Zhejiang, China;Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, China;Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, China;Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;Jinan Microecological Biomedicine Shandong Laboratory, Shandong First Medical University, Jinan, Shandong, China;School of Biological Engineering, Hangzhou Medical College, Institute of Parasitic Diseases, Hangzhou, Zhejiang, China;School of Clinical Medicine, Institute of Hepatology and Metabolic Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang, China;

关键词: Akkermansia muciniphila;    Alzheimer’s disease;    depression;    microbiota-gut-brain axis;    neuropsychiatric disorders;   

DOI  :  10.3389/fcimb.2023.1224155

 received in 2023-05-17, accepted in 2023-06-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

An accumulating body of evidence suggests that the bacterium Akkermansia muciniphila exhibits positive systemic effects on host health, mainly by improving immunological and metabolic functions, and it is therefore regarded as a promising potential probiotic. Recent clinical and preclinical studies have shown that A. muciniphila plays a vital role in a variety of neuropsychiatric disorders by influencing the host brain through the microbiota-gut-brain axis (MGBA). Numerous studies observed that A. muciniphila and its metabolic substances can effectively improve the symptoms of neuropsychiatric disorders by restoring the gut microbiota, reestablishing the integrity of the gut mucosal barrier, regulating host immunity, and modulating gut and neuroinflammation. However, A. muciniphila was also reported to participate in the development of neuropsychiatric disorders by aggravating inflammation and influencing mucus production. Therefore, the exact mechanism of action of A. muciniphila remains much controversial. This review summarizes the proposed roles and mechanisms of A. muciniphila in various neurological and psychiatric disorders such as depression, anxiety, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, strokes, and autism spectrum disorders, and provides insights into the potential therapeutic application of A. muciniphila for the treatment of these conditions.

【 授权许可】

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Copyright © 2023 Lei, Cheng, Gao, Liu, Shao, Kong, Zheng, Ling and Hu