Formins and membranes: anchoring cortical actin to the cell wall and beyond

Frontiers in Plant Science

卷:4

Fatima eCvrckova¹ 

[1] Charles University in Prague, Faculty of Science;

关键词: Cell Polarity;    Endocytosis;    Actin;    formin;    vesicle trafficking;    plasmalemma;   

DOI  :  10.3389/fpls.2013.00436

来源: DOAJ

【 摘 要 】

Formins are evolutionarily conserved eukaryotic proteins participating in actin and microtubule organization. Land plants have three formin clades, with only two – Class I and II – present in angiosperms. Class I formins are often transmembrane proteins, residing at the plasmalemma and anchoring the cortical cytoskeleton across the membrane to the cell wall, while Class II formins possess a PTEN-related membrane-binding domain. Lower plant Class III and non-plant formins usually contain domains predicted to bind RHO GTPases that are membrane-associated. Thus, some kind of membrane anchorage appears to be a common formin feature. Direct interactions between various non-plant formins and integral or peripheral membrane proteins have indeed been reported, with varying mechanisms and biological implications. Besides of summarizing new data on Class I and Class II formin-membrane relationships, this review surveys such non-classical formin-membrane interactions and examines which, if any, of them may be evolutionarily conserved and operating also in plants. FYVE, SH3 and BAR domain-containing proteins emerge as possible candidates for such conserved membrane-associated formin partners.

【 授权许可】

Unknown