RHAMM Is a Multifunctional Protein That Regulates Cancer Progression

International Journal of Molecular Sciences

卷:22

Britney J. Messam¹  Eva A. Turley²  Cornelia Tolg²  James B. McCarthy³  Andrew C. Nelson³ 

[1] Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ONN6A 5C1, Canada;

[2] London Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, ON N6A 4L6, Canada;

[3] Masonic Cancer Center, Department of Laboratory Medicine and Pathology, Minneapolis, MN 55455, USA;

关键词: RHAMM;    HA;    signaling;    domains;    isoforms;    evolution;   

DOI  :  10.3390/ijms221910313

来源: DOAJ

【 摘 要 】

The functional complexity of higher organisms is not easily accounted for by the size of their genomes. Rather, complexity appears to be generated by transcriptional, translational, and post-translational mechanisms and tissue organization that produces a context-dependent response of cells to specific stimuli. One property of gene products that likely increases the ability of cells to respond to stimuli with complexity is the multifunctionality of expressed proteins. Receptor for hyaluronan-mediated motility (RHAMM) is an example of a multifunctional protein that controls differential responses of cells in response-to-injury contexts. Here, we trace its evolution into a sensor-transducer of tissue injury signals in higher organisms through the detection of hyaluronan (HA) that accumulates in injured microenvironments. Our goal is to highlight the domain and isoform structures that generate RHAMM’s function complexity and model approaches for targeting its key functions to control cancer progression.

【 授权许可】

Unknown