Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review

International Journal of Molecular Sciences

卷:23

Jarosław Mołdoch¹  Iwona Kowalska¹  Anna Oniszczuk²  Karolina Wojtunik-Kulesza²  Tomasz Oniszczuk³  Jarosław Szponar⁴ 

[1] Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, 24-100 Puławy, Poland;

[2] Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland;

[3] Department of Thermal Technology and Food Process Engineering, University of Life Sciences in Lublin, Głęboka 31, 20-612 Lublin, Poland;

[4] Toxicology Clinic, Clinical Department of Toxicology and Cardiology, Medical University of Lublin, Stefan Wyszyński Regional Specialist Hospital, Al. Kraśnicka 100, 20-718 Lublin, Poland;

关键词: Alzheimer’s disease;    neurodegeneration;    dementia;    polyphenols;    terpenes;    secondary plant metabolites;   

DOI  :  10.3390/ijms23031212

来源: DOAJ

【 摘 要 】

Neurodegenerative disorders such as Alzheimer’s disease (AD) are distinguished by the irreversible degeneration of central nervous system function and structure. AD is characterized by several different neuropathologies—among others, it interferes with neuropsychiatrical controls and cognitive functions. This disease is the number one neurodegenerative disorder; however, its treatment options are few and, unfortunately, ineffective. In the new strategies devised for AD prevention and treatment, the application of plant-based natural products is especially popular due to lesser side effects associated with their taking. Moreover, their neuroprotective activities target different pathological mechanisms. The current review presents the anti-AD properties of several natural plant substances. The paper throws light on products under in vitro and in vivo trials and compiles information on their mechanism of actions. Knowledge of the properties of such plant compounds and their combinations will surely lead to discovering new potent medicines for the treatment of AD with lesser side effects than the currently available pharmacological proceedings.

【 授权许可】

Unknown