TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy

Frontiers in Aging Neuroscience

卷:11

Lumi Zhang¹  Guoping Peng¹  Yi Chen¹  Yunyun Wang²  Min Liu³ 

[1] Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;

[2] Department of Neurology, Shengzhou People’s Hospital, Shengzhou, China;

[3] Department of Neurology, Zhejiang University ShuLan International Hospital, Hangzhou, China;

关键词: TDP-43;    neuropathology;    Alzheimer’s disease;    neurodegeneration;    hippocampal sclerosis;    dementia;   

DOI  :  10.3389/fnagi.2019.00376

来源: DOAJ

【 摘 要 】

Through a number of an extensive autopsy, biomarker, and genomics studies, researchers have recently defined a novel type of dementia known as limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE is perhaps best characterized by the presence of hyperphosphorylated TDP-43, which plays multi-functional roles through interactions with DNA and RNA, leading to significant alterations in the transcription and translation of particular genes. As individuals of advanced age represent a rapidly growing demographic group globally, there is a steadily increasing rate of LATE incidence that has to date received insufficient recognition despite its serious implications for public health. TDP-43 is the common pathology of various age-related dementia, therefore, it may be a potential and promising therapeutic target for such diseases. In the present review, we discuss the pathways regulating TDP-43 expression, metabolism, and disease activity in order to better understand the link between TDP-43 proteinopathy and LATE at the genetic, pathological, and clinical levels.

【 授权许可】

Unknown