Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet?

Journal of Neuroinflammation

Gabriele C DeLuca¹  Olaf Ansorge¹  Margaret M Esiri¹  Grace Li² 

[1] Nuffield Department of Clinical Neurosciences (Neuropathology), University of Oxford, Oxford, UK;Clinical Medical School, University of Oxford, Oxford, UK

关键词: neurodegeneration;    inflammation;    neuropathology;    amyotrophic lateral sclerosis;    multiple sclerosis;   

Others  :  1212844
DOI  :  10.1186/1742-2094-9-20

 received in 2011-11-18, accepted in 2012-01-24,  发布年份 2012

【 摘 要 】

The concurrence of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) is exceedingly rare and the pathological features have not been examined extensively. Here we describe the key pathological features of a 40 year old man with pathologically confirmed concurrent MS and ALS.

This is the most pathologically illustrative case of coincident MS and ALS demonstrating inflammatory and neurodegenerative features characteristic of each disease, and is the first to exhibit the presence of TDP-43 inclusions in this clinical entity. The intricate relationship between neuroinflammation and neurodegeneration in these diseases is discussed.

【 授权许可】

   
2012 Li et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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