Potential Bidirectional Relationship Between Periodontitis and Alzheimer’s Disease

Frontiers in Physiology

Daniela Liccardo¹  Federica Marzano²  Leonardo Bencivenga²  Federica Carraturo³  Marco Guida³  Alessandra Valletta⁴  Carlo Rengo⁵  Imma Melino⁶  Grazia Daniela Femminella⁶  Armida Addonizio⁶  Jacopo Agrimi⁷  Nicola Ferrara⁸  Giuseppe Rengo⁸  Alessandro Cannavo⁹ 

[1] Center for Translational Medicine, Temple University, Philadelphia, PA, United States;Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy;Department of Biology, University of Naples Federico II, Naples, Italy;Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy;Department of Prosthodontics and Dental Materials, School of Dental Medicine, University of Siena, Siena, Italy;Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy;Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States;Istituti Clinici Scientifici ICS Maugeri - S.p.A.-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Scientifico di Telese Terme, Telese, Italy;Task Force on Microbiome Studies, University of Naples Federico II, Naples, Italy;

关键词: Alzheimer’s disease;    periodontitis;    dysbiosis;    neurodegeneration;    dementia;   

DOI  :  10.3389/fphys.2020.00683

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly population, representing a global public health priority. Despite a large improvement in understanding the pathogenesis of AD, the etiology of this disorder remains still unclear, and no current treatment is able to prevent, slow, or stop its progression. Thus, there is a keen interest in the identification and modification of the risk factors and novel molecular mechanisms associated with the development and progression of AD. In this context, it is worth noting that several findings support the existence of a direct link between neuronal and non-neuronal inflammation/infection and AD progression. Importantly, recent studies are now supporting the existence of a direct relationship between periodontitis, a chronic inflammatory oral disease, and AD. The mechanisms underlying the association remain to be fully elucidated, however, it is generally accepted, although not confirmed, that oral pathogens can penetrate the bloodstream, inducing a low-grade systemic inflammation that negatively affects brain function. Indeed, a recent report demonstrated that oral pathogens and their toxic proteins infect the brain of AD patients. For instance, when AD progresses from the early to the more advanced stages, patients could no longer be able to adequately adhere to proper oral hygiene practices, thus leading to oral dysbiosis that, in turn, fuels infection, such as periodontitis. Therefore, in this review, we will provide an update on the emerging (preclinical and clinical) evidence that supports the relationship existing between periodontitis and AD. More in detail, we will discuss data attesting that periodontitis and AD share common risk factors and a similar hyper-inflammatory phenotype.

【 授权许可】

Unknown