The Differences in the Level of Anti-SARS-CoV-2 Antibodies after mRNA Vaccine between Convalescent and Non-Previously Infected People Disappear after the Second Dose—Study in Healthcare Workers Group in Poland

Vaccines

卷:9

Maciej Zacharski¹  Sylwia Brodzka²  Ewa Wałecka-Zacharska³  Aneta Mańkowska-Cyl⁴  Eugenia Gospodarek-Komkowska⁵  Alicja Sękowska⁵  Zuzanna Kraszewska⁵  Katarzyna Grudlewska-Buda⁵  Joanna Kwiecińska-Piróg⁵  Jana Przekwas⁵  Krzysztof Skowron⁵  Natalia Wiktorczyk-Kapischke⁵ 

[1] Department of Biochemistry and Molecular Biology, Wroclaw University of Environmental and Life Sciences, 50-375 Wrocaw, Poland;

[2] Department of Biotechnology, Faculty of Biological Science, University of Zielona Gora, 65-417 Zielona Gora, Poland;

[3] Department of Food Hygiene and Consumer Health, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland;

[4] Department of Laboratory Medicine, Nicolaus Copernicus University in Toruń, L. Rydygier Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland;

[5] Department of Microbiology, Nicolaus Copernicus University in Toruń, L. Rydygier Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland;

关键词: antibodies;    SARS-CoV-2;    vaccination;    immunological response;   

DOI  :  10.3390/vaccines9121402

来源: DOAJ

【 摘 要 】

(1) Background: In many infections, antibodies play a crucial role in controlling infection. In COVID-19, the dynamics of the immune system response to SARS-CoV-2 is not fully understood. (2) Methods: The study was conducted on 120 healthcare workers from Dr. Antoni Jurasz University Hospital No. 1 in Bydgoszcz, between June and December 2020. In all participants, IgA and IgG antibody serum concentrations were measured using the semi-quantitative Anti-SARS-CoV-2 ELISA test (Euroimmun). After vaccination, in January and February 2021, antibody levels were examined using the quantitative IgG Anti-SARS-CoV-2 Quantivac ELISA test (Euroimmun). (3) Results: During the whole study period, the SARS-CoV-2 infection was confirmed in 29 (24.2%) participants. In all infected participants, IgA and IgG antibodies were detectable after infection by semi-quantitative serological tests. Levels of antibodies were higher one month after the first dose in the convalescents than in the non-previously infected participants. In this second group, the level of antibodies increased significantly after the second dose of vaccines compared to the first dose. (4) Conclusions: The level of antibodies after the first dose of vaccine in the convalescents’ group is higher than in the SARS-CoV-2 non-infected group, but the differences disappear after the second vaccination.

【 授权许可】

Unknown