Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis

Journal of Functional Foods

卷:15

Allen Y. Chen¹  Yon Rojanasakul²  Yi Charlie Chen³  Haizhi Huang³  Xingqian Ye⁴  Gary O. Rankin⁴ 

[1]College of Science, Technology &|Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA

[2]|College of Biosystems Engineering and Food Science, Fuli Institute of Food Science, Zhejiang University, China

[3]|Department of Pharmaceutical Science, West Virginia University, Morgantown, WV 26506, USA

关键词: Galangin;    Myricetin;    p21;    Angiogenesis;    Ovarian cancer;   

DOI  :  

来源: DOAJ

【 摘 要 】

Galangin and myricetin are flavonoids isolated from vegetables and fruits which exhibit anti-proliferative activity in human cancer cells. In this study, their anti-angiogenic effects were investigated with in vitro (HUVEC) and in vivo (CAM) models, which showed that galangin and myricetin inhibited angiogenesis induced by OVCAR-3 cells. The molecular mechanisms through which galangin and myricetin suppress angiogenesis were also studied. It was observed that galangin and myricetin inhibited secretion of the key angiogenesis mediator vascular endothelial growth factor (VEGF) and decreased levels of p-Akt, p-p70S6K and hypoxia-inducible factor-1α (HIF-1α) proteins in A2780/CP70 and OVCAR-3 cells. Transient transfection experiments showed that galangin and myricetin inhibited secretion of VEGF by the Akt/p70S6K/HIF-1α pathway. Moreover, a novel pathway, p21/HIF-1α/VEGF, was found to be involved in the inhibitory effect of myricetin on angiogenesis in OVCAR-3 cells. These data suggest that galangin and myricetin might serve as potential anti-angiogenic agents in the prevention of ovarian cancers dependent on new blood vessel networks.

【 授权许可】

Unknown