Molecules | 卷:20 |
Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives | |
Jia-Jia Xin1  Ming-Kai Li2  Xin-Liang Du3  Chun Li4  Feng Sui4  Hai Ma4  Zhu-Ju Wang4  Yun-Peng Sui4  Hai-Yu Zhou4  Hai-Ru Huo4  Hong-Dan Zhan4  Xiao-Jun Li5  Jing Li5  | |
[1] Department of Blood Transfusion, Xijing Hospital, the Fourth Military Medical University,Xi’an 710032, China; | |
[2] Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University,Xi’an 710032, China; | |
[3] Graduate School of China Academy of Chinese Medical Sciences, Beijing 100700, China; | |
[4] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; | |
[5] The Key Laboratory for Surface Engineering and Remanufacturing in Shaanxi Province,School of Chemical Engineering, Xi’an University, Xi’an 710065, China; | |
关键词: biscoumarin; dihydropyran; antibacterial; antitumor; | |
DOI : 10.3390/molecules200917614 | |
来源: DOAJ |
【 摘 要 】
A novel series of biscoumarin (1–4) and dihydropyran (5–13) derivativeswere synthesized via a one-pot multicomponent condensation reaction and evaluated for antibacterial and antitumor activity in vitro. The X-ray crystal structure analysis of four representative compounds, 3, 7, 9 and 11, confirmed the structures of these compounds. Compounds 1–4 showed the most potent antitumor activity among the total 13 derivatives; especially for compounds 1 and 2, they also emerged as promising antibacterial members with better antibacterial activity. In addition, the results of density functional theory(DFT) showed that compared with compounds 3 and 4, biscoumarins 1 and 2 had lower intramolecular hydrogen bonds (HB) energy in their structures.
【 授权许可】
Unknown