Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives

Molecules

卷:20

Jia-Jia Xin¹  Ming-Kai Li²  Xin-Liang Du³  Chun Li⁴  Feng Sui⁴  Hai Ma⁴  Zhu-Ju Wang⁴  Yun-Peng Sui⁴  Hai-Yu Zhou⁴  Hai-Ru Huo⁴  Hong-Dan Zhan⁴  Xiao-Jun Li⁵  Jing Li⁵ 

[1] Department of Blood Transfusion, Xijing Hospital, the Fourth Military Medical University,Xi’an 710032, China;

[2] Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University,Xi’an 710032, China;

[3] Graduate School of China Academy of Chinese Medical Sciences, Beijing 100700, China;

[4] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;

[5] The Key Laboratory for Surface Engineering and Remanufacturing in Shaanxi Province,School of Chemical Engineering, Xi’an University, Xi’an 710065, China;

关键词: biscoumarin;    dihydropyran;    antibacterial;    antitumor;   

DOI  :  10.3390/molecules200917614

来源: DOAJ

【 摘 要 】

A novel series of biscoumarin (1–4) and dihydropyran (5–13) derivativeswere synthesized via a one-pot multicomponent condensation reaction and evaluated for antibacterial and antitumor activity in vitro. The X-ray crystal structure analysis of four representative compounds, 3, 7, 9 and 11, confirmed the structures of these compounds. Compounds 1–4 showed the most potent antitumor activity among the total 13 derivatives; especially for compounds 1 and 2, they also emerged as promising antibacterial members with better antibacterial activity. In addition, the results of density functional theory(DFT) showed that compared with compounds 3 and 4, biscoumarins 1 and 2 had lower intramolecular hydrogen bonds (HB) energy in their structures.

【 授权许可】

Unknown