Functional implications of Rab27 GTPases in Cancer

Cell Communication and Signaling

卷:16

Jia Fang¹  Shasha He²  Tang Liu³  Rui Fang³  Zhihong Li³ 

[1] Department of Neurology, The Second Xiangya Hospital, Central South University;

[2] Department of Oncology, The Second Xiangya Hospital, Central South University;

[3] Department of Orthopaedics, The Second Xiangya Hospital, Central South University;

关键词: Rab27;    Small GTPase;    Exosome;    Tumor microenvironment;    Cancer;   

DOI  :  10.1186/s12964-018-0255-9

来源: DOAJ

【 摘 要 】

Abstract Background The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. Main body Elevated expression of Rab27 GTPases is associated with poor prognosis and cancer metastasis. Moreover, these GTPases govern a variety of oncogenic functions, including cell proliferation, cell motility, and chemosensitivity. In addition, small GTPases promote tumor growth and metastasis by enhancing exosome secretion, which alters intracellular microRNA levels, signaling molecule expression, and the tumor microenvironment. Conclusion Rab27 GTPases may have applications as prognostic markers and therapeutic targets in cancer treatment.

【 授权许可】

Unknown