Mechanochemical Dimerization of Aldoximes to Furoxans

Molecules

卷:27

Chuang Niu¹  Run-Kai Fang¹  Kuan Chen¹  Guan-Wu Wang¹ 

[1] Hefei National Laboratory for Physical Sciences, Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China;

关键词: mechanochemistry;    aldoximes;    furoxans;    nitrile oxides;    dimerization;   

DOI  :  10.3390/molecules27082604

来源: DOAJ

【 摘 要 】

Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis. The mechanochemical solvent-free synthesis of furoxans from aldoximes was achieved through dimerization of the in situ generated nitrile oxides in the presence of sodium chloride, Oxone and a base. A variety of furoxans was obtained with up to a 92% yield. The present protocol has the advantages of high reaction efficiency and mild reaction conditions.

【 授权许可】

Unknown