Head and neck cancer in young adults treated with 3-D conformal radiotherapy

Archive of Oncology

卷:18

关键词: Head and Neck Neoplasms;    Young Adults;    Radiotherapy;    Conformal;   

DOI  :  10.2298/AOO1003060S

来源: DOAJ

【 摘 要 】

Background: Purpose of this study was to determine patterns of failure inyoung adults with head and neck cancer treated with 3-D conformalradiotherapy. Methods: Twenty-eight patients with head and neck canceryounger than 41 years of age were treated with 3-D conformal radiotherapy.Patients’ median age was 31.4 years. Radiotherapy was delivered in the mediantotal dose of 67.2 Gy to PTV (range, 60.0-70.0 Gy) with or without concurrentcisplatin. Results: The median duration of follow-up was 20 months. Distantmetastases were the most frequent pattern of failure. The locoregionalrelapse-free survival (LRR-FS) rate at 2 years was 66.6%. The median durationof LRR-FS was 15 months. The distant metastases relapse-free survival(DMR-FS) rate at 2 years was 65.7%. The median duration of DMR-FS was also 15months. The overall survival (OS) rate at 2 years was 57.2%. The medianduration of OS was 20 months. Conclusion: Radiotherapy with or withoutconcurrent chemotherapy plays an important role in treatment of patients withhead and neck cancer. Recent developments of new radiotherapy techniques haveincreased rates of local control. Distant metastases remain the most frequentpattern of failure in this group of young adults with head and neck cancer.Introducing new cytotoxic and target therapies in future could lead to betteroutcome in this subgroup of patients.

【 授权许可】

Unknown